Composite patch versus biological patch in the repair of canine abdominal wall defects

doi:10.3969/j.issn.2095-4344.2016.12.012

Abstract

Abstract:

BACKGROUND: Currently a big controversy erupts in the repair of abdominal wall defects with composite patch.
OBJECTIVE: To compare the composite patch and biological patch in the repair of abdominal wall defects in dogs.
METHODS: Ten dogs were selected to prepare abdominal wall defect models, and then randomized into experimental group subjected to composite patch repair and control group subjected to biological patch repair. Incision adhesion was assessed at postoperative 30, 60, 90 days; patches and defect tissues were taken and detected histologically at postoperative 14 days.
RESULTS AND CONCLUSION: The incision adhesion in the experimental group was milder than that in the control group at different time post operation (P < 0.05). At 14 days post operation, the material structure was clear with no signs of absorption in the experimental group, and there were a large amount of infiltrated inflammatory cells around the patch material, such as neutrophils and lymphocytes, and non-phagocytic patch was found; in the control group, the material structure was fuzzy with the presence of inflammatory cell infiltration and slight signs of absorption. Moreover, inflammation and fibrosis were severer in the control group than the experimental group. These findings indicate that compared with the biological patch, the composite patch is better to effectively reduce inflammatory reactions.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Duan You-liang, Lin Ao. Composite patch versus biological patch in the repair of canine abdominal wall defects[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(12): 1753-1756.

Figures/Tables 3

References

[1] Zhong T,Janis JE,Ahmad J,et al.Outcomes after abdominal wall reconstruction using acellular dermal matrix: a systematic review.J Plast Reconstr Aesthet Surg.2011;64(12):1562-1571．

[2] Johnson EK,Paquette EL.Use of surgisis for abdominal wall reconstruction / closure in battlefield casualties during operation iraqi Free-dom.Mil Med.2007;172 (10):1119-1124．

[3] 刘飞德,李基业,姚胜,等．异体脱细胞真皮基质修补31例腹壁疝及缺损[J].中国修复重建外科杂志,2010,24(10): 1253-1256．

[4] 陈革,唐健雄,黄磊,等.生物补片在治疗感染和污染腹壁缺损方面的体会(附34例病例)[J].中华疝和腹壁外科杂志:电子版,2011,5(4):389-393．

[5] Beres A,Christison-Lagay ER,Romao RL,et al. Evaluation of Surgisis for patch repair of abdominal wall defects in children.J Pediatr Surg.2012;7(5): 917-919．

[6] Cavallaro A,Lo Menzo E,Di Vita M,et al.Use of biological meshes for abdominal wall reconstruction in highly contaminated fields.World J Gastroenterol. 2010; 16(15):1928-1933．

[7] Janfaza M,Martin M,Skinner R.A preliminary comparison study of two noncrosslinked biologic meshes used in complex ventral hernia repairs.World J Surg.2012;36(8):1760-1764．

[8] Itani KM,Rosen M,Vargo D,et al.Prospective study of single-stage repair of contaminated hernias using a biologic porcine tissue matrix: the RICH Study.Surgery. 2012;152(3):498-505．

[9] Zhong T,Janis JE,Ahmad J,et al.Outcomes after abdominal wall reconstruction using acellular dermal matrix: a systematic review.J Plast Reconstr Aesthet Surg.2011;64 (12):1562-1571

[10] Johnson EK,Paquette EL.Use of surgisis for abdominal wall reconstruction / closure in battlefield casualties during operation iraqi Freedom.Mil Med.2007;172(10): 1119-1124．

[11] 刘飞德,李基业,姚胜,等．异体脱细胞真皮基质修补31例腹壁疝及缺损[J].中国修复重建外科杂志,2010,24(10): 1253-1256．

[12] 陈革,唐健雄,黄磊,等.生物补片在治疗感染和污染腹壁缺损方面的体会(附34例病例)[J].中华疝和腹壁外科杂志:电子版,2011,5(4):389-393．

[13] Cavallaro A,Lo Menzo E,Di Vita M,et al.Use of biological meshes for abdominal wall reconstruction in highly contaminated fields.World J Gastroenterol. 2010;16(15):1928-1933．

[14] Janfaza M,Martin M,Skinner R.A preliminary comparison study of two noncrosslinked biologic meshes used in complex ventral hernia repairs.World J Surg.2012;36(8):1760-1764．

[15] Itani KM,Rosen M,Vargo D,et al.Prospective study of single-stage repair of contaminated hernias using a biologic porcine tissue matrix: the RICH Study. Surgery. 2012;152(3):498-505．

[16] Mondalek FG,Ashley RA,Roth CC,et al.Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly (lactide-co- glycolide) nanoparticles: from fabrication to preclinical validation.J Biomed Mater Res A.2010;94(3): 712-719．

[17] Suckow MA,Hodde JP,Wolter WR,et al.Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in rats.J Biomed Mater Res B Appl Biomater.2010;93(1):18-23．

[18] Zhou HY,Zhang J,Yan RL,et al.Improving the antibacterial property of porcine small intestinal submucosa by nano-silver supplementation: a promising biological material to address the need for contaminated defect repair.Ann Surg.2011;253(5): 1033-1041.

[19] Huang SP,Hsu CC,Chang SC,et al.Adipose-derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murine model of a full-thickness defect.Ann Plast Surg.2012;69(6): 656-662．

[20] 宋致成,顾岩.应用猪小肠黏膜下层与肌腱细胞构建组织工程支架修复成年雄性普通犬腹壁缺损的实验研究[J].外科理论与实践,2012,17(3):270-274．

[21] 曾逃方,罗旭,辛国华,等.激光微孔化猪脱细胞真皮基质的设计、制备及同步移植实验[J].上海交通大学学报(医学版),2012,32(10):1307-1311．

[22] 刘昶,李金松,纪艳超．生物补片在疝外科的应用及相关研究进展[J].中华疝和腹壁外科杂志:电子版,2013,7(2): 109-112．

[23] Omidi H,Tahmasebi Z,Naghdi Badi HA,et al.Fatty acid composition of canola (Brassica napus L,as affected by agronomical,genotypic and environmental parameters.C R Biol.2010;333(3):248-254．

[24] ten Broek RP,Stommel MW,Strik C,et al.Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis.Lancet.2014; 383(9911):48-59．

[25] Yigitler C,Karakas DO,Kucukodaci Z.Adhesion- preventing properties of 4% icodextrin and canola oil: a comparative experi-mental study.Clinics.2012;67(11): 1303-1308．

[26] Catena F,Ansaloni L,Di SS,et al. P． O． P． A． Study: pP.O.P.A. study: prevention of postoperative abdominal adhesions by icodextrin 4% solution after laparotomy for adhesive small bowel obstruction. A prospective randomized controlled trial.J Gastrointest Surg.2012;16(2): 382-388．

[27] 侯欣欣,张皓,张东生.磁性纳米颗粒作为基因载体的研究进展[J].医学研究生学报,2013,26(2):186-189．

[28] Park KS,Lee KE,Ku do H,et al.Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy: a prospective,randomized controlled study. J Korean Surg Soc.2013;84(6):321-329．

[29] 陈艳军,高旭珍,张艳杰,等.高山红景天对肝纤维化成年雄性普通犬Smad3mRNA 表达的影响[J].医学研究生学报, 2012,25(12):1242-1246．

[30] Li L,Wang N,Jin X.Biodegradable and injectable in situ crosslinking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention.Biomaterials. 2014;35(12):3903-3917．

[31] 曹飞,周军.超声引导下经贵要静脉纵横切面联合进针在经外周静脉穿刺中心静脉置管中的应用价值[J].中华医学超声杂志(电子版),2012,9(7):645-647.

[32] 匡毅,蒋又新,李福沛,等.带蒂背阔肌肌皮瓣修复腹壁巨大缺损的临床疗效分析[J].第三军医大学学报,2013,35(15): 1643-1645

[33] 廖秀媚.米非司酮联合手术治疗剖宫产术后腹壁切口子宫内膜异位症的疗效分析[J].中国当代医药,2013,20(8): 54-55．

[34] 邓姗,冷金花,郎景和,等．腹壁子宫内膜异位症术前预测补片的可行性分析[J].国际妇产科学杂志,2013,40(4): 364-368．

[35] 曾德强,陈双,杨斌.壳聚糖膜预防术后腹腔粘连及其作用机制的研究[J].岭南现代临床外科,2005,5(2):94-96．

[36] 王莲莲,曹霞,罗希,等.几丁糖和透明质酸钠防粘连材料在妇产科的应用[J].中国组织工程研究,2012,16(47): 8923-8930．

[37] 肖海军,侯春林,薛锋．羧甲基壳聚糖－羧甲基纤维素防粘连膜的制备及其理化特性[J].中国组织工程研究与临床康复,2010,14(38):7069-7074．

[38] 张少锋,洪加源.医用生物可吸收止血材料的研究现状与临床应用[J].中国组织工程研究,2012,16(21): 3941-3944．

[39] 邝婉容,曾煦欣,杨安平,等.丹参防治术后粘连的研究进展[J].中国民族民间医药,2009,33(14):17-18．

[40] Takagi K,Araki M,Fukuoka H,et al.Novel powdered anti-adhesion material: preventing postoperative intra-ab-dominal adhesions in a rat model.Int J Med Sci.2013;(10):467-474．